发明名称 |
Imidazo[2,1-b]thiazole derivatives as sirtuin modulators |
摘要 |
<p>Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.</p> |
申请公布号 |
EP2388263(A1) |
申请公布日期 |
2011.11.23 |
申请号 |
EP20110075196 |
申请日期 |
2006.08.04 |
申请人 |
SIRTRIS PHARMACEUTICALS, INC. |
发明人 |
BEMIS, JEAN;VU, CHI;NG, PUI YEE;DISCH, JEREMY S;NUNES, JOSEPH;MILNE, JILL;XIE, ROGER |
分类号 |
C07D498/04;A61K31/41;A61K31/435;A61K31/495;A61P3/00;A61P7/00;A61P9/00;A61P21/00;A61P25/00;A61P27/00;A61P35/00;A61P39/00;C07D235/18;C07D401/12;C07D403/12;C07D513/04 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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