Humanized anti-9 integrin antibodies and the uses thereof

摘要

The present invention provides humanized antibodies that immunospecifically recognize human ±9 integrin. Some of these antibodies inhibit the biological functions of the ±9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with ±9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g. , rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.