发明名称 |
MALATE SALT OF N- (4- { [ 6, 7-BIS (METHYLOXY) QUINOLIN-4-YL]OXY}PHENYL-N' - (4 -FLUOROPHENYL) CYCLOPROPANE-1,1-DICARBOXAMIDE, AND CRYSTALLINE FORMS THEREOF FOR THE TREATMENT OF CANCER |
摘要 |
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide. |
申请公布号 |
EP2387563(A1) |
申请公布日期 |
2011.11.23 |
申请号 |
EP20100701175 |
申请日期 |
2010.01.15 |
申请人 |
EXELIXIS, INC.;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BROWN, ADRIAN ST. CLAIR;LAMB, PETER;GALLAGHER, WILLIAM, P. |
分类号 |
C07D215/227;A61K31/47;A61P35/00 |
主分类号 |
C07D215/227 |
代理机构 |
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主权项 |
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地址 |
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