6-(HETEROCYCLE-SUBSTITUTED BENZYL)-4-OXOQUINOLINE COMPOUND AND USE OF THE SAME AS HIV INTEGRASE INHIBITOR

摘要

The present invention relates to a compound represented by the following formula [I] (see formula [I]) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical composition, an anti-HIV agent and an HIV integrase inhibitor containing such compound. In some aspects, the compound of the present invention has an HIV integrase inhibitory activity, and may be useful as an anti-HIV agent, or as an agent for the prophylaxis or treatment of AIDS. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it may be a more effective anti-HIV agent. Because it shows integrase-specific inhibitory activity, the compound may be a pharmaceutical agent which is safe to use and which causes fewer side effects.