发明名称 |
Compositions and methods of making a photoactive agent |
摘要 |
An improved two stage reaction process for production of mono-L-aspartyl chlorin e6. In a first stage, the activation reaction between chlorin e6 and a carbodiimide produces a previously unknown anhydride in an activation reaction product. This reaction product is purified to remove a significant proportion of the precursors of di-L-aspartyl chlorin e6. The purified activation reaction product contains a higher concentration of the previously unknown anhydride. This purified reaction product is used in a second stage: a coupling reaction of the purified activation reaction product with aspartate. The coupling reaction produces a coupling reaction product that has significantly reduced di-L-aspartyl chlorin e6 concentration. This reduced di-L-aspartyl chlorin e6 concentration facilitates purification of mono-L-aspartyl chlorin e6 from the coupling reaction mixture.
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申请公布号 |
US8063203(B2) |
申请公布日期 |
2011.11.22 |
申请号 |
US20100917353 |
申请日期 |
2010.11.01 |
申请人 |
XU LEON;PALLENBERG ALEXANDER J.;LIGHT SCIENCES ONCOLOGY, INC. |
发明人 |
XU LEON;PALLENBERG ALEXANDER J. |
分类号 |
C07D487/22 |
主分类号 |
C07D487/22 |
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