发明名称 |
Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
摘要 |
Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. |
申请公布号 |
US8063224(B2) |
申请公布日期 |
2011.11.22 |
申请号 |
US20070998501 |
申请日期 |
2007.11.30 |
申请人 |
LACHANCE NICOLAS;LI CHUN SING;LECLERC JEAN-PHILIPPE;RAMTOHUL YEEMAN K.;MERCK CANADA INC. |
发明人 |
LACHANCE NICOLAS;LI CHUN SING;LECLERC JEAN-PHILIPPE;RAMTOHUL YEEMAN K. |
分类号 |
C07D401/00;A61K31/445 |
主分类号 |
C07D401/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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