发明名称 GlyT1 receptor antagonists
摘要 The present invention relates to a compound of formula I wherein R1, R2, X, Ar1 and Ar2 are as defined herein and to pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to their corresponding enantiomers and/or optical isomers thereof. Compounds of the invention are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors.
申请公布号 US8063098(B2) 申请公布日期 2011.11.22
申请号 US20090541202 申请日期 2009.08.14
申请人 KOLCZEWSKI SABINE;NARQUIZIAN ROBERT;PINARD EMMANUEL;HOFFMANN-LA ROCHE INC. 发明人 KOLCZEWSKI SABINE;NARQUIZIAN ROBERT;PINARD EMMANUEL
分类号 A61K31/40;C07D207/04 主分类号 A61K31/40
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