发明名称 |
Method for producing L-lysine |
摘要 |
An Escherichia bacterium having dihydrodipicolinate synthase and aspartokinase, both of which are desensitized to feedback inhibition by L-lysine. The intracellular activity of dihydrodipicolinate reductase in this bacterium can also be enhanced. Furthermore, a diaminopimelate dehydrogenase gene can be introduced into this bacterium, or intracellular activities of tetrahydrodipicolinate succinylase and succinyl diaminopimelate deacylase can be enhanced. Finally, the intracellular activities of aspartate-semialdehyde dehydrogenase or phosphoenolpyruvate carboxylase can be enhanced in this bacterium. The bacterium can be cultured in a suitable medium to produce and accumulate L-lysine in culture, and the L-lysine is collected from the culture. |
申请公布号 |
US8062869(B2) |
申请公布日期 |
2011.11.22 |
申请号 |
US20100721813 |
申请日期 |
2010.03.11 |
申请人 |
NAKANISHI KAZUO;KIKUCHI YOSHIMI;KOJIMA JUNICHIRO;SUZUKI TOMOKO;NISHIMURA YASUSHI;KOJIMA HIROYUKI;AJINOMOTO CO., INC. |
发明人 |
NAKANISHI KAZUO;KIKUCHI YOSHIMI;KOJIMA JUNICHIRO;SUZUKI TOMOKO;NISHIMURA YASUSHI;KOJIMA HIROYUKI |
分类号 |
C12P13/08;C12N1/21;C12N15/52 |
主分类号 |
C12P13/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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