发明名称 |
Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process |
摘要 |
<p>There is provided a process for preparing a salt of the (R)- or (S)-isomer of 1- naphthylethylamine with mandelic acid or a derivative thereof, the process comprising reacting racemic 1-naphthylethylamine with mandelic acid or a derivative thereof to obtain the (R)- or (S)-isomer of 1-naphthylethylamine salt (III) with the acid. The salts also form an aspect of the present invention. There is also provided a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof. There is also provided a process for preparing cinacalcet (I) or a salt thereof, the process comprising reacting an ester (II) with (R)-i-naphthylethylamine or a salt of (R)-i-naphthylethylamine and mandelic acid or a derivative thereof, to obtain cinacalcet, and optionally converting the cincalcet to a salt thereof.</p> |
申请公布号 |
AU2010219464(A8) |
申请公布日期 |
2011.11.17 |
申请号 |
AU20100219464 |
申请日期 |
2010.03.04 |
申请人 |
CIPLA LIMITED |
发明人 |
KANKAN, RAJENDRA NARAYANRAO;RAO, DHARMARAJ RAMACHANDRA;BIRARI, DILIP RAMDAS |
分类号 |
C07C209/16;C07C59/50;C07C211/30 |
主分类号 |
C07C209/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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