发明名称 |
Methods of Preparing 1-Deoxy-Sphingoid Bases and Derivatives Thereof |
摘要 |
Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, regioselective epoxide-opening, hydrogenation, and dihydroxylation. The methods described herein provide 1-deoxy-sphingoid bases and derivatives in high overall yield and high enantiomeric purity.
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申请公布号 |
US2011282081(A1) |
申请公布日期 |
2011.11.17 |
申请号 |
US201013143611 |
申请日期 |
2010.01.21 |
申请人 |
LIEBESKIND LANNY S.;GARNIER-AMBLARD ETHEL C.;LIOTTA DENNIS C.;EMORY UNIVERSITY |
发明人 |
LIEBESKIND LANNY S.;GARNIER-AMBLARD ETHEL C.;LIOTTA DENNIS C. |
分类号 |
C07D301/14;C07C213/08;C07F7/18 |
主分类号 |
C07D301/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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