ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF
摘要
<p>The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.</p>
申请公布号
WO2011143124(A2)
申请公布日期
2011.11.17
申请号
WO2011US35775
申请日期
2011.05.09
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;HAURWITZ, RACHEL E.;DOUDNA, JENNIFER A.;WIEDENHEFT, BLAKE;JINEK, MARTIN
发明人
HAURWITZ, RACHEL E.;DOUDNA, JENNIFER A.;WIEDENHEFT, BLAKE;JINEK, MARTIN