NUCLEIC ACID-CONTAINING LIPID PARTICLES AND RELATED METHODS
摘要
The present invention provides a method for preparing nucleic acid-lipid nanoparticles comprising the cationic lipid DLinKC2-DMA using a microfluidic mixing device, wherein the resulting nucleic acid-lipid nanoparticles exhibit smaller particle diameter and greater core density than nucleic acid-lipid nanoparticles of the same formulation produced b/ the conventional preformed vesicle method
申请公布号
CA2816925(A1)
申请公布日期
2011.11.17
申请号
CA20102816925
申请日期
2010.11.04
申请人
THE UNIVERSITY OF BRITISH COLUMBIA
发明人
BELLIVEAU, NATHAN M.;CULLIS, PIETER R.;HAFEZ, ISMAIL;HANSEN, CARL LARS GENGHIS;HUFT, JENS;LEUNG, ALEX;MALCOM, STUART;TAYLOR, JAMES;WALKER, DAVID;WILD, ANDRE