COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS
摘要
The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
申请公布号
WO2011143669(A2)
申请公布日期
2011.11.17
申请号
WO2011US36701
申请日期
2011.05.16
申请人
DANA-FARBER CANCER INSTITUTE, INC;BRADNER, JAMES, ELLIOTT;QI, JUN