PEPTIDE- POLYNUCLEOTIDE COMPOSITIONS FOR TRANSFECTING A CELL WITH DNA AND FOR TREATING A NEURODEGENERATIVE DISEASE

摘要

Peptide-polynucleotide compositions and conjugates for the treatment of neurodegenerative disease are provided. The compositions and conjugates contain a peptide having one or more of a rabies virus glycoprotein domain, a nuclear localization signal domain, and a DNA condensing domain that is linked either covalently or electrostatically to polynucleotides such as shRNA. Methods of transfecting a cell with DNA, methods of increasing shRNA expression in target cells of a mammal, and methods of treatment are also provided, which include delivery of the peptide-polynucleotide compositions and conjugates of the invention.