USE OF HISTONE ACETYLTRANSFERASE INHIBITORS AS NOVEL ANTI-CANCER THERAPIES
摘要
The present invention provides methods for treating cancer comprising inhibiting the activity of p300/CBP histone acetyltransferase (HAT). Also provided are p300/CBP HAT inhibitors for treating a subject having cancer. In addition, the present invention includes biomarkers for p300/CBP HAT inhibition, which are used to i) monitor the effectiveness of cancer therapy, and ii) identify anti-cancer agents for use in combination therapy.
申请公布号
WO2011085039(A3)
申请公布日期
2011.11.17
申请号
WO2011US20271
申请日期
2011.01.05
申请人
THE JOHNS HOPKINS UNIVERSITY;ALANI, RHODA, MYRA;COLE, PHILIP, A.;YAN, GAI;BOWERS, ERIN, M.
发明人
ALANI, RHODA, MYRA;COLE, PHILIP, A.;YAN, GAI;BOWERS, ERIN, M.
