发明名称 |
MODULATION OF SCLERAXIS USING A DOMINANT NEGATIVE SCLERAXIS MUTANT WITH A BASIC DNA-BINDING DOMAIN DELETION |
摘要 |
Compositions and kits for modulating expression of scleraxis and/or collagen synthesis in mammalian cells and tissues. The compositions and kits comprise a protein comprising an amino acid sequence that shares at least 75% homology with SEQ ID NO:11. Proteins comprising amino acid sequences that share at least 75% homology with SEQ ID NO: 11 are expressed by mutants of scleraxis gene wherein a nucleotide sequence comprising a basic DNA binding domain has been deleted. Such mutants are exemplified by basic domain deletion Scx?BD mutants that comprise nucleotide sequences sharing at least 75% homology with SEQ ID NO:8 or SEQ ID NO: 10. Methods for modulating fibrosis in a subject comprising administration of a composition comprising at least one physiologically effective dosage of a protein comprising a polypeptide molecule comprising an amino acid sequence that shares at least 75% homology with SEQ ID NO: 11. |
申请公布号 |
WO2011140639(A1) |
申请公布日期 |
2011.11.17 |
申请号 |
WO2011CA00547 |
申请日期 |
2011.05.10 |
申请人 |
UNIVERSITY OF MANITOBA;CZUBRYT, MICHAEL P. |
发明人 |
CZUBRYT, MICHAEL P. |
分类号 |
C12N15/12;A61K38/17;C07K14/47;C12N1/19;C12N1/21 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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