发明名称 |
SUBSTITUTED N-HETEROARYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF |
摘要 |
<p>The present invention discloses and claims a series of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of Formula (I). Wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of Formula (I) and intermediates therefor.</p> |
申请公布号 |
WO2011143155(A1) |
申请公布日期 |
2011.11.17 |
申请号 |
WO2011US35835 |
申请日期 |
2011.05.10 |
申请人 |
SANOFI;GAO, ZHONGLI;HARTUNG, RYAN |
发明人 |
GAO, ZHONGLI;HARTUNG, RYAN |
分类号 |
C07D401/14;A61K31/4709;A61P25/00;C07D403/14;C07D413/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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