发明名称 |
Combinatorial therapy involving alpha5beta1 antagonists |
摘要 |
The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them. |
申请公布号 |
EP2366716(A3) |
申请公布日期 |
2011.11.16 |
申请号 |
EP20110156484 |
申请日期 |
2007.03.21 |
申请人 |
GENENTECH, INC. |
发明人 |
CHUNTHARAPAI, ANAN;PLOWMAN, GREG;TESSIER-LAVIGNE, MARC;WU, YAN;YE, WEILAN |
分类号 |
C07K16/28;A61K39/395;A61P17/02;A61P35/00;C07K16/22;G01N33/74 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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