| 摘要 |
Transcriptional regulatory regions and transcriptional regulatory factors for the human high affinity IgE receptor (Fc&egr;RI) γ-chain gene are specified and are targets for the development of transcriptional regulatory agents for the Fc&egr;RI γ-chain gene. The following are provided: DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:1, that regulates transcription of the human high affinity IgE receptor (Fc&egr;RI) γ-chain gene; and DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:2, that regulates transcription of the human high affinity IgE receptor (Fc&egr;RI) γ-chain gene. The present invention is promising for the development of novel agents for the prophylaxis/treatment of allergic diseases, autoimmune diseases, thrombosis, glomerulonephritis, and lupus nephritis. |
