发明名称 |
KCNN3 ALS DIAGNOSTISCHES UND THERAPEUTISCHES TARGET FÜR ALZHEIMER-KRANKHEIT |
摘要 |
The present invention discloses a dysregulation of the KCNN3 gene and the protein products thereof in Alzheimer's disease patients and individuals being at risk of developing Alzheimer's disease. Based on this finding, the invention provides methods for diagnosing and prognosticating Alzheimer's disease in a subject, and for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating and preventing Alzheimer's disease and related neurodegenerative disorders using the KCNN3 gene and its corresponding gene products. Screening methods for modulating agents of neurodegenerative diseases are also disclosed. |
申请公布号 |
AT530667(T) |
申请公布日期 |
2011.11.15 |
申请号 |
AT20060763326T |
申请日期 |
2006.05.29 |
申请人 |
EVOTEC NEUROSCIENCES GMBH |
发明人 |
POHLNER, JOHANNES;VON DER KAMMER, HEINZ |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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