ENGINEERED E2 FOR INCREASING THE CONTENT OF FREE LYS11- LINKED UBIQUITIN
摘要
The invention provides a chimeric E2 enzyme comprising a Ubc domain fused to a heterologous ubiquitin binding domain (UBD). The chimeric enzymes of the invention are useful in producing elevated levels of free polyubiquitin.
申请公布号
WO2011138593(A1)
申请公布日期
2011.11.10
申请号
WO2011GB00704
申请日期
2011.05.06
申请人
MEDICAL RESEARCH COUNCIL;KOMANDER, DAVID;BREMM, DR ANJA
