BPB-BASED CARGO DELIVERY SYSTEM

摘要

The present invention relates to a BPB-based cargo delivery system, comprising: (a) bipodal peptide binder (BPB) including (i) a structure-stabilizing region that includes parallel, antiparallel, or parallel and antiparallel amino acid strands in which interstrand non-covalent bonds are formed, and (ii) a target-binding region I and a target-binding region II which are bonded to both terminals of the structure-stabilizing region and which include randomly selected n and m amino acids, respectively; and (b) a cargo bonded to the BPB. The BPB-based cargo delivery system of the present invention can deliver various substances onto or into cells by using the target-bonding and target-specific characteristics of the BPB. The BPB has a very low KD value (dissociation constant) (for example, nM level) and therefore exhibits a very high affinity toward a target. The BPB-based cargo delivery system of the present invention can be used in the fields of medicine, in vivo molecular imaging, in vitro cell imaging, and drug delivery targeting, and can be very useful as an escort molecule.