发明名称 |
NOVEL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE AND AIRWAY INFLAMMATION |
摘要 |
Provided are compositions and methods for treating inflammation due to an immune response. Non-limiting example compositions include class-2 SPATE proteins that are capable of cleaving proteins involved in an inflammatory immune response in a patient. Example compositions include at least one mucin-cleaving class-2 SPATE protein. Further example compositions include protein involved in intestinal colonization (Pic). Non-limiting example methods include methods of decreasing inflammation in a patient having inflammation and methods of perturbing immune response in a patient having a disease or condition in which an active immune response is attributable to a cause of the disease or condition, by administering to the patient a composition including at least one class-2 SPATE protein capable of cleaving proteins involved in an inflammatory immune response. |
申请公布号 |
WO2011087835(A3) |
申请公布日期 |
2011.11.10 |
申请号 |
WO2010US61758 |
申请日期 |
2010.12.22 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;NATARO, JAMES P.;RUIZ-PEREZ, FERNANDO |
发明人 |
NATARO, JAMES P.;RUIZ-PEREZ, FERNANDO |
分类号 |
A61K39/02;A61K39/112;A61K39/395;A61P1/00;A61P29/00 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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