发明名称 |
CHIMERIC ACTIVATORS: QUANTITATIVELY DESIGNED PROTEIN THERAPEUTICS AND USES THEREOF |
摘要 |
Aspects of the invention provide methods for harnessing the potential of proteins that occur naturally (e.g., in humans) and that have serious but finite toxicity. Aspects of the invention relate to a quantitative systems-biological and structural approach to design a class Mof chimeric proteins that avoid the toxicity of protein drugs while retaining their desired activities. In particular, chimeric proteins containing a variant form of a natural protein fused to a targeting moiety may be administered to a subject to target a signal (e.g., induction of apoptosis) to particular cells without having a generalized toxic effect |
申请公布号 |
US2011274658(A1) |
申请公布日期 |
2011.11.10 |
申请号 |
US20080594747 |
申请日期 |
2008.04.05 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
SILVER PAMELA A.;CIRONI PABLO;MIGUEZ DAVID G. |
分类号 |
A61K38/21;A61K38/19;A61K39/395;A61P3/04;A61P7/06;A61P11/06;A61P31/18;A61P35/00;C07H21/00;C07K1/00;C07K19/00 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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