发明名称 |
METHODS FOR DETECTING METABOLIC STATES BY LASER ABLATION ELECTROSPRAY IONIZATION MASS SPECTROMETRY |
摘要 |
According to certain embodiments, a method of mass spectrometry may generally comprise subjecting a sample comprising at least one indicator to laser ablation electrospray ionization mass spectrometry; determining a relative intensity of the indicator; and comparing the relative intensity of the indicator to a standard indicator intensity. Subjecting a sample to laser ablation electrospray ionization mass spectrometry may comprise ablating the sample with an infrared laser under ambient conditions to form an ablation plume; intercepting the ablation plume by an electrospray plume; and detecting the indicator by mass spectrometry. The method of mass spectrometry may comprise classifying the sample as belonging to or not belonging to the standard indicator intensity. A sample not belonging to the standard indicator intensity may indicate that the sample is predicted to comprise a disease state.
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申请公布号 |
CA2798182(A1) |
申请公布日期 |
2011.11.10 |
申请号 |
CA20102798182 |
申请日期 |
2010.05.05 |
申请人 |
GEORGE WASHINGTON UNIVERSITY |
发明人 |
VERTES, AKOS;KASHANCHI, FATAH;SRIPADI, PRABHAKAR;KEHNHALL, KYLENE |
分类号 |
H01J49/16;H01J49/04;H01J49/26 |
主分类号 |
H01J49/16 |
代理机构 |
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