INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE

摘要

Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ?adhE?ldhA?iclR?ack-pta plus PYC+ and NAD+-dependant FDH+. Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ?adhE?ldhA?iclR?ack-pta plus PYC+ and NAD+-dependant FDH+.Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ?adhE?ldhA?iclR?ack-pta plus PYC+ and NAD+-dependant FDH+.