发明名称 |
METHOD FOR DETECTING BIOLOGICAL MARKERS BY AN ATOMIC FORCE MICROSCOPE |
摘要 |
A method for detecting biological markers involves preparing sample slices using a hard granular labeling material such as hard nano-gold granular material. The sample slices are fixed to sample patches. The sample is scanned using the atomic force microscope (AFM) in tapping mode to collect the height, amplitude and phase data of the hard granular material. The hard labeling material is mainly determined through changes in discrepancies in phase diagram color, while height and amplitude diagrams are used to provide auxiliary evidence of sample morphological features. Integrating these data with the state of the biological target object can thus determine the existence of a marked object. |
申请公布号 |
US2011275092(A1) |
申请公布日期 |
2011.11.10 |
申请号 |
US200813129422 |
申请日期 |
2008.12.31 |
申请人 |
CHINESE ACADEMY OF INSPECTION AND QUARANTINE |
发明人 |
HU KONGXIN;ZHANG LIPING;PING RUIJIN |
分类号 |
G01N33/53;G01Q30/20 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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