| 发明名称 |
GENOME EDITING OF A ROSA LOCUS USING ZINC-FINGER NUCLEASES |
| 摘要 |
Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. |
| 申请公布号 |
CA2796600(A1) |
申请公布日期 |
2011.11.10 |
| 申请号 |
CA20112796600 |
申请日期 |
2011.04.25 |
| 申请人 |
SANGAMO BIOSCIENCES, INC.;SIGMA ALDRICH CO. LLC |
发明人 |
CUI, XIAOXIA;DAVIS, GREGORY;GREGORY, PHILIP D.;HOLMES, MICHAEL C.;WEINSTEIN, EDWARD J. |
| 分类号 |
C12N9/22;C07K19/00;C12N9/96;C12N15/00;C12N15/09;C12N15/55;C12N15/62;C12N15/90;C12P19/34 |
主分类号 |
C12N9/22 |
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