| 摘要 |
Platinum (II) complexes having N-alkyl substituted trans-1,2-diaminocyclohexanes as ligands and the preparation method thereof are provided. The structures of the platinum (II) complexes having N-alkyl substituted trans-1,2-diaminocyclohexanes as ligands are as shown by formula (1a) and formula (1b), in which Y is an anion of organic carboxylic acid, Z is a dianion of organic dicarboxylic acid, and R is C3-8 alkyl. The said preparation method is as follows: using trans-1,2-diaminocyclohexane protected by mon-Boc as a starting material to obtain the compound represented by formula (3), then reacting it with potassium platinate tetrahalide to obtain the said compound of formula (2), reacting the compound of formula (2) to obtain the said compound of formula (1a) or formula (1b). The platinum (II) complexes shown by formula (1a) and formula (1b) in the present invention have obvious inhibition on human liver cancer cells HepG-2, human breast cancer cells MCF-7, human lung cancer cells A549, and human colon cancer cells HCT-116.
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