发明名称 |
Anti-CepsilonmX antibodies capable of binding to human mIgE on B lymphocytes |
摘要 |
<p>The invention pertains to the generation and utility of antibodies that can bind effectively to CεmX domain on membrane-bound IgE (mIgE) expressed on the surface of human B lymphocytes. The CεmX domain of 52 amino acid residues, located between the CH4 domain and the C-terminal membrane-anchor peptide on human membrane-bound epsilon chain, had been suggested as an antigenic site for immunological targeting of B cells expressing mlgE. Previous reported monoclonal antibodies, including a20, which bind to RADWPGPP peptide at the C-terminal of CεmX, have now been found to bind poorly to mlgE on human B cells. We have discovered that only monoclonal antibodies specific for certain segments, such as GLAGGSAQSQRAPDRVL and HSGQQQGLPRAAGGSVPHPR, of CεmX can bind effectively to mlgE on human B cells and hence have the utility for targeting those B cells for the treatment of diseases mediated by IgE.</p> |
申请公布号 |
AU2010217100(A8) |
申请公布日期 |
2011.11.10 |
申请号 |
AU20100217100 |
申请日期 |
2010.02.25 |
申请人 |
HUNG, ALFUR;CHEN, JIUN-BO;WU, PHEIDIAS;CHANG, TSEWEN |
发明人 |
CHANG, TSEWEN;CHEN, JIUN-BO;WU, PHEIDIAS C.;HUNG, ALFUR F. |
分类号 |
C07K16/28;A61K38/10;A61K39/395;A61P37/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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