发明名称 |
PROCESS FOR OBTAINING A CONCENTRATE OF VON WILLEBRAND FACTOR OF A COMPLEX OF FACTOR VIII/VON WILLEBRAND FACTOR AND USE OF THE SAME |
摘要 |
A method of treating a patient suffering from Haemophilia A and/or Von Willebrand's disease involves administering the patient a concentrate of Von Willebrand Factor (VWF) or a complex of Factor VIII/VWF prepared by creating a solution of VWF or a complex of Factor VIII/VWF containing VWF at a concentration of up to 12 IU VWF:RCo/ml and a VWF/Factor VIII ratio of 0.4 or more, and nanofiltering that starting solution through a filter of pore size of about 35 nm or smaller. The resulting VWF retains high molecular weight multimers.
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申请公布号 |
US2011275570(A1) |
申请公布日期 |
2011.11.10 |
申请号 |
US201113164117 |
申请日期 |
2011.06.20 |
申请人 |
GRIFOLS, S.A. |
发明人 |
JORQUERA NIETO JUAN IGNACIO;RISTOL DEBART PERE;FARO TOMAS MARIA MERCEDES |
分类号 |
A61K38/37;A61P7/04 |
主分类号 |
A61K38/37 |
代理机构 |
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代理人 |
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地址 |
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