发明名称 |
CAPSULAR GRAM-POSITIVE BACTERIA BIOCONJUGATE VACCINES |
摘要 |
An embodiment of the present invention is directed to a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines comprising: a protein carrier comprising an inserted nucleic acid consensus sequence; at least one polysaccharide such as a capsular Gram-positive polysaccharide linked to the consensus sequence; and, optionally, an adjuvant or pharmaceutically acceptable carrier. In a further aspect, the instant invention is directed to methods of producing Gram-positive and other bioconjugate vaccines. In another aspect, an N-glycosylated protein is provided that comprises one or more polysaccharides such as Gram-positive polysaccharides. The present invention is additionally directed to engineered prokaryotic organisms comprising nucleotide sequences encoding a glycosyltransferase of a first prokaryotic organism and a glycosyltransferase of a second prokaryotic organism. The invention further includes plasmids and prokaryotic cells transformed with plasmids encoding polysaccharides and enzymes which produce an N-glycosylated protein and/or bioconjugate vaccine. Further, the invention is directed to methods of inducing an immune response in a mammal comprising administering said bioconjugate vaccines. |
申请公布号 |
WO2011138361(A1) |
申请公布日期 |
2011.11.10 |
申请号 |
WO2011EP57111 |
申请日期 |
2011.05.04 |
申请人 |
GLYCOVAXYN;WACKER, MICHAEL;KOWARIK, MICHAEL;WETTER, MICHAEL |
发明人 |
WACKER, MICHAEL;KOWARIK, MICHAEL;WETTER, MICHAEL |
分类号 |
A61K39/085 |
主分类号 |
A61K39/085 |
代理机构 |
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代理人 |
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