NEW PHARMACEUTICAL DOSAGE FORM FOR THE TREATMENT OF GASTRIC ACID-RELATED DISORDERS

摘要

According to the invention there is provided a pharmaceutical composition for peroral administration to the gastrointestinal tract comprising: (i) a plurality of granules comprising a pharmacologically effective amount of a micronised H2 receptor antagonist or a pharmaceutically acceptable salt thereof granulated together with a disintegrant; and (ii) a pharmaceutically acceptable carrier, wherein the granules (i) are distributed homogeneously within the carrier (ii). The compositions of the invention are particularly useful in the treatment of gastric acid secretion-related disorders, such as gastro-esophageal reflux disease.