| 摘要 |
The invention relates to a process for the preparation of a pharmaceutical preparation for oral administration, comprising a storable suspension of viable eggs of parasitic helminths which are nonpathogenic to humans. viz. Trichuris suis, where, after the ingestion of the suspension, a sufficient number of helminths develops to result in a stimulation of regulatory human T-cells. The suspension of the helminth eggs is subjected, in one step, to an acid treatment at a pH of <=2 and in that, in a further step, the pH is adjusted to >=4 and a pharmacologically acceptable preservative is added. The invention further relates to a pharmaceutical preparation for oral administration, comprising a storable suspension of viable eggs of parasitic helminths which are nonpathogenic to humans, viz. Trichuris suis, where, after the ingestion of the suspension, a sufficient number of helminths develops to result in a stimulation of regulatory T-cells, the suspension comprising fewer than 1000 colony-forming microorganisms per ml of suspension, the pharmaceutical preparation is prepared by the process as claimed. |
