发明名称 |
PROCESS FOR THE PREPARATION OF METHYL-METHYL-3, 4-DIHYDRO-2H-PYRAN-5-CARBOXYLATE |
摘要 |
The present invention provides an improved process for the preparation of methyl-methyl-3,4-dihydro-2H-pyran-5-carboxylate of formula (IV), comprising the steps of: (IV) (i) alkylating 1-Bromo-3-chloropropane of formula (I) with Methylacetoacetate of formula (II) to prepare haloketone of formula (VII) in presence of an alcoholic solvent; (I) (II) (VII) (ii) O-alkylating the compound of formula (VII) with sodium methoxide to obtain the desired molecule methyl-methyl-3,4-dihydro-2H-pyran-5-carboxylate of formula (IV) in its crude form; (VII) (IV) (iii) Purifying the content of step (ii) above by fractional distillation to obtain the purified molecule of formula (IV). |
申请公布号 |
WO2011108001(A3) |
申请公布日期 |
2011.11.10 |
申请号 |
WO2011IN00111 |
申请日期 |
2011.02.24 |
申请人 |
SPC LIFESCIENCES PVT LTD |
发明人 |
PATEL, SNEHAL R.;RAKESH, P.N. ROSHAN |
分类号 |
C07D309/28 |
主分类号 |
C07D309/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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