| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to pharmaceutical industry, namely, to obtaining form-stable hydrogel matrices, intended for addressed prolonged release of medications, demonstrating regenerating, wound-healing, anti-inflammatory immunostimulating or antioxidant activity. Obtaining of form-stable hydrogels based on sodium alginate and chitosan with addition of salts of diacids can be realised by interaction of initial substances in two versions - by introduction into volume of water solution of sodium algenate with small content of chitosan of colloidal solutions of insoluble salts of diacids (method of reinforcement) or in mixing water solutions of sodium algenate and chitosan with superficial processing with soluble salts of diacids (method of submerging). ^ EFFECT: advantage of claimed method in comparison with known methods lies in possibility to give hydrogel required three-dimensional shape and its soft, non-traumatising surface, which makes it possible to use it for prolonged release of medications in affected cavities (for instance, oral) as well as complete biocompatibility and possibility to change rate of medication release by varying concentration of linking agent purposefully. ^ 2 cl, 16 ex |
