| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention describes method of predicting risk of development of therapeutic resistance in patients with bronchial asthma, by analysis of patients blood 3 month after beginning of treatment, DNA, separated from lymphocytes of peripheral venous patients blood, is analysed, values of levels of genes INC2, INC3, GJA8, SV2 expression are determined by microchips Affymetrix and probability of relating individuum to group with high risk of developing therapeutic resistance and low risk of therapeutic resistance development, and, R1 for individuums with high risk of therapeutic resistance development is estimated by formula: R1=-351.966-, 274*INC2+46.608*INC3+129.530*GLA8+105.438*SV2A, where 274; 46.608; 129.530; 105.438 - numeric values are coefficients; (-351.966) is constant for individuums with high risk of BA development; INC2, INC3, GJA8, SV2 are genotytpes, and R2 for individuums with low risk of therapeutic resistance development is calculated by formula: R2=-403.217-64.874*INC2+55.603*INC3+141.648*GJA8+116.342*SV2A, where 64.874; 55.603; 141.648; 116.342 are numeric values which are coefficients; (-403.217) is constant for individuums with high risk of BA and at R1>R2 high risk is predicted , and at R1<R2 low risk of therapeutic resistance is predicted in patient with bronchial asthma. ^ EFFECT: increase of accuracy and self-descriptiveness. ^ 4 ex, 3 tbl |
