METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION BY MEDICATION ETOXYDOL IN CASE OF L-NAME INDUCED NITROGEN OXIDE DEFICIENCY

摘要

FIELD: medicine. ^ SUBSTANCE: in order to correct endothelial dysfunction white male rats of Wistar line have endothelial dysfunctions modelled by intro-peritoneum introduction of N-nitro-L-arginine methyl ether in dose 25 mg/kg daily, for seven days. Degree of dysfunction development is estimated by ratio of indices of endothelium-independent and endothelium-dependent vasodilation. Correction of endothelial dysfunction is carried out by intra-peritoneum introduction of medicine "Etoxydol" in dose 25 mg/kg one time per day, for 7 days in the morning. ^ EFFECT: correction of endothelial dysfunction by novel derivative of 3-oxypyridine in specially developed for this purpose dose and mode of medication introduction. ^ 2 tbl, 1 ex