发明名称 |
Modified rodent parvovirus capable of propagating and spreading through human gliomas |
摘要 |
Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in semi-permissive human tumor cells, and (b) parvovirus variants capable of propagating and spreading through human tumor cells characterized by particular amino acid deletions and/or substitutions, e.g. a deletion of several amino acids in the C-terminus of NS1/middle exon of NS2. A pharmaceutical composition containing such parvoviruses as well as their use for the treatment of cancer, preferably a glioblastoma, is also described. |
申请公布号 |
EP2384761(A1) |
申请公布日期 |
2011.11.09 |
申请号 |
EP20100004897 |
申请日期 |
2010.05.07 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM |
发明人 |
NUEESCH, JUERG;THOMAS, NADJA;PLOTZKY, CLAUDIA;ROMMELAERE, JEAN |
分类号 |
A61K35/76;C12N7/00 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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