发明名称 |
Protecting group for carboxylic acids that can be photolyzed by visible light |
摘要 |
The present invention relates to a photolabile compound including a coumarin family caging group covalently bound to an organic moiety containing a carboxyl group, an amino group, a sulfhydryl group, and/or a hydroxyl group. The photolabile compound, upon absorbing visible light, releases the organic moiety. Also disclosed is a method of making a photolabile compound that releases a biologically active compound upon absorbing visible light by providing an organic moiety and binding a coumarin family caging group to the organic moiety under conditions effective to make the photolabile compound. The present invention also relates to a method of obtaining a biologically active compound in a sample. The method involves adding to a sample a photolabile compound including a coumarin family caging group covalently bound to an organic moiety. The sample is then illuminated with visible light under conditions effective to obtain a biologically active compound including the organic moiety.
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申请公布号 |
US8053585(B2) |
申请公布日期 |
2011.11.08 |
申请号 |
US20060402715 |
申请日期 |
2006.04.12 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
HESS GEORGE P.;CARPENTER BARRY K.;SHEMBEKAR VISHAKHA R.;CHEN YONGLI |
分类号 |
C07D311/02;C07C229/00;C07C261/00 |
主分类号 |
C07D311/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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