THE QHINAZOLINE DERIVATIVES WHICH ARE INHIBITOR OF ADP-RIBOSYL CYCLASES

摘要

PURPOSE: A quinazoline derivative which controls the activity of ADP-ribosyl cyclase(ADPR-cyclase) is provided to suppress intracellular calcium increase. CONSTITUTION: An ADPR-cyclase inhibitor contains quinazoline derivatives of chemical formula 1. In chemical formula 1, R1, R2, R3, R4, and R5 are hydrogen, halogen atoms, low alkyl group of 1-6 carbon atoms. The derivative of chemical formula 1 is 6,8-dimehty-N-[1-(naphthalene-1-yl)ethyl]quinazoline-1-amine. An agent of preventing and treating kidney and cardiovascular diseases contains the quinazoline derivative of chemical formula 1.