OPTIMIZATION OF CROSSOVER POINT FOR DIRECTED EVOLUTION

摘要

PROBLEM TO BE SOLVED: To provide a method for producing libraries of biomolecules that are enriched for functional biomolecules.

SOLUTION: Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids includes: for example, a variety of methods for selecting and/or assessing potential crossover sites in an amino acid sequence or a nucleotide sequence; and the resulting chimeric product sequences. The methods include, e.g. consideration of structural, functional and/or statistical data in the selection and assessment of sequences and crossover sites for use in recombination.

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