| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a non-human knockout animal where PI3K-C2α gene is deleted, to provide a method for creating the same, and to provide application using the knockout animal and the animal-derived tissues/cells. <P>SOLUTION: The non-human knockout animal and offspring animals thereof are provided which keep the functions of part or the whole of PI3K-C2α gene deleted each on the homologous chromosome, and represent disorders or symptoms associated with angiogenesis and/or neovascularization. Tissues/cells derived from the animal are also provided. Besides, a method for screening candidate substance(s) for preventing and/or treating the disorders or symptoms, and a method for screening biomarker(s) for the disorders or symptoms, each using the animal and/or the tissues/cells, are provided. <P>COPYRIGHT: (C)2012,JPO&INPIT |
