RECOMBINANT FILAGGRIN POLYPEPTIDES FOR CELL IMPORTATION
摘要
Disclosed are recombinant polypeptides that include (a) a f?laggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.
申请公布号
WO2011063320(A3)
申请公布日期
2011.11.03
申请号
WO2010US57592
申请日期
2010.11.22
申请人
RESEARCH DEVELOPMENT FOUNDATION;STOUT, TIMOTHY, J.;APPUKUTTAN, BINOY;MCFARLAND, TREVOR