| 摘要 |
This invention refers to new 1,2,3-triazole and imidazole compounds included in the families of compounds represented by general formula VIII. where: X is an atom of“C”or“N”where X is“N”the radicals do triazole ring are represented by: R1=COR2, CSR3, CN(R4)R5 or CF2R6; R2=H, NHNH2, alkyl, aryl substituted or not, OH, NR7R8 or OR9 R3=alkyl or aryl substituted or not R4=H, OH, alkyl or aryl substituted or not R5=R6=R7=R8=R9=R10=H, alkyl or aryl substituted or not where X is“C”the radicals do imidazolic ring are represented by: R1=COR2 R2=NHNH2, OH, OR3, or NR4R5 R3=alkyl or aryl substituted or not R4=R5=H, alkyl or aryl substituted or not R10=NHR6 or NR6R7 R6=R7=COR8 R8=aryl substituted or not while radical Rn can be located in any one or in more than one of the carbon atoms of the aromatic ring, and these radicals can be equal or different, represented by hydrogen, alkylic groups with 1 or more carbon atoms in a linear or branched chain alkenes or alkynes, hydroxyl, hydroxyalkyl or oxygenated functions in acyclic or cyclic systems forming an heterocyclic ring, free or substituted amines, thioalkyl, donators and/or removing groupings of electrons or halogens, thus“n”can vary from 1 to 5. This invention also refers to a pharmaceutical composition comprising, as active principle, at least one of the azole compounds represented by the general formula VIII, to the use of such compositions and to method of treatment or inhibition de tuberculosis and leishmaniasis.
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