| 摘要 |
The present invention relates to a medical stent coated with a photosensitizer, and a preparation method thereof, and more specifically, to a composition for coating a stent for photodynamic therapy, comprising a photosensitizer, a non-degradable polymer and an organic solvent, a medical stent coated with a photosensitizer, comprising a layer coated with the coating composition, a preparation method of the stent, and photodynamic therapy using the stent. A medical stent coated with the coating composition according to the present invention, is prepared by dissolving a photosensitizer and a non-degradable polymer in an organic solvent; coating a stent with a coating solvent where the photosensitizer and the non-degradable polymer are dissolved; and volatilizing the coating solvent. Excellent treatment effects can be induced in vivo even after a long time since a photosensitizer, which is a pharmaceutically active material, is adhered to a stent for a long time by a non-degradable polymer, and a patient can be up and around outside after operation since only target cells can be selectively treated according to whether light is irradiated, in vivo side effects are small compared with known photodynamic therapy through transdermal or oral administration and it is possible to repeatedly carry out operations several times. |
