发明名称 |
HCV ENTRY FACTOR, OCCLUDIN |
摘要 |
The human Occludin protein is identified as an essential Hepatitis C Virus (HCV) cell entry factor. Occludin is shown to render murine and other non-human cells infectable with HCV and to be required for HCV—susceptibility of human cells. Associated methods for inhibiting HCV infection, transgenic animal models for HCV pathogenesis, methods of identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin, and HCV inhibitory agents are also disclosed. Kits and cell culture compositions useful for identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin are also provided.
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申请公布号 |
US2011271356(A1) |
申请公布日期 |
2011.11.03 |
申请号 |
US200913122339 |
申请日期 |
2009.10.01 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
PLOSS ALEXANDER;EVANS MATTHEW;RICE CHARLES |
分类号 |
A01K67/00;A61K31/7088;A61K38/02;A61K39/395;A61P31/14;C12Q1/68;C40B30/00;G01N33/566 |
主分类号 |
A01K67/00 |
代理机构 |
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