发明名称 |
SYSTEMS AND METHODS FOR ANALYZING NUCLEIC ACID SEQUENCES |
摘要 |
Nucleic acid sequence mapping/assembly methods are disclosed. The methods initially map only a contiguous portion of each read to a reference sequence and then extends the mapping of the read at both ends of the mapped contiguous portion until the entire read is mapped (aligned). In various embodiments, a mapping score can be calculated for the read alignment using a scoring function, score (i, j) = M+mx, where M can be the number of matches in the extended alignment, x can be the number of mismatches in the alignment, and m can be a negative penalty for each mismatch. The mapping score can be utilized to rank or choose the best alignment for each read. |
申请公布号 |
WO2011137368(A2) |
申请公布日期 |
2011.11.03 |
申请号 |
WO2011US34611 |
申请日期 |
2011.04.29 |
申请人 |
LIFE TECHNOLOGIES CORPORATION;ZHANG, ZHENG;GUO, DANWEI;LOU, YUANDAN;BRINZA, DUMITRU |
发明人 |
ZHANG, ZHENG;GUO, DANWEI;LOU, YUANDAN;BRINZA, DUMITRU |
分类号 |
G06F19/22;C12Q1/68;G06F19/28 |
主分类号 |
G06F19/22 |
代理机构 |
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