发明名称 |
COMPOSITE PROBES AND USE THEREOF IN SUPER RESOLUTION METHODS |
摘要 |
Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions. |
申请公布号 |
WO2011090710(A3) |
申请公布日期 |
2011.11.03 |
申请号 |
WO2010US62214 |
申请日期 |
2010.12.28 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;KNUTSON, JAY, R.;GRIFFITHS, GARY, L. |
发明人 |
KNUTSON, JAY, R.;GRIFFITHS, GARY, L. |
分类号 |
G01N33/52;G01N21/64;G01N33/58 |
主分类号 |
G01N33/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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