CCN3 AND USES THEREOF AGAINST METABOLIC SYNDROME- ASSOCIATED DISORDERS

摘要

The present invention relates to the use of at least one AMPK activator such as a CCN3 polypeptide or a functional derivative thereof, a CCN3 polynucleotide or a functional fragment thereof, a polypeptide encoded by CCN3 polynucleotide or a functional fragment thereof, or an agent capable of up-regulating CCN3 gene expression in the subject for treating or preventing a metabolic-syndrome associated disorder in a subject. The present invention also relates to methods for the diagnostic of metabolic-syndrome associated disorder in a subject using CCN3 polypeptide or polynucleotide.